The value of creating intensive, tissue-particular maps of protein lysine acetylation sites is further underscored by the significant position of posttranslational modifications within the evolution and phenotypic composition of vertebrates, as indicated by the significant selective stress gene regulatory components near posttranslational-modifying enzymes have come beneath in placental animals ( Lowe et al., legal 2011 ). Right here, we mixed an efficient technique for protein extraction from tissue samples with lysine-acetylated peptide immunoprecipitation and high-accuracy tandem mass spectrometric (MS/MS) measurements, which allowed us to generate an atlas of lysine acetylation sites in sixteen completely different rat tissues.

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