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These important capabilities could also be associated to MOF-mediated acetylation of chromatin-associated proteins apart from H4 or alterations of chromatin construction induced by such modifications that aren't detectable by DNaseI sensitivity.

The exception to the rule is the DOT1 family, members of which methylate K79 in the globular region of histone H3 and that are structurally not related to SET-domain proteins 4 - 6 Current work means that SET-domain-containing proteins methylate a number of proteins along with histones (see later)