In clinical research, when Lysine hydrochloride (the shape it is metabolized greatest from) is taken in concentrations of less than 1250mg (2 x 625mg tablets) it has a restricted impact on the Herpes and chilly sore virus - and when taken at a daily dose greater than 3000mg it's proven to be doubtlessly unsafe. The exception to the rule is the DOT1 family, members of which methylate K79 within the globular area of histone H3 and which are structurally not related to SET-area proteins four - 6 Current work suggests that SET-domain-containing proteins methylate a few proteins along with histones (see later)